Researchers from the University of Minnesota, USA found that the human immunodeficiency virus (HIV) bind to and destroy specific antiviral proteins in the human body called APOBEC3F. The results of this study open the possibility of the presence of a new approach to combating HIV / AIDS by utilizing the antiviral activity of certain proteins.
Human cells produce antiviral proten apolipoprotein B mRNA editing enzyme, catalytic polypeptide (APOBEC) that have unique and natural ability to destroy HIV. However, HIV develop ways to overcome obstacles by using a protein called virion infectivity factor (VIF) to lower the APOBEC proteins and make the virus spread.
According to John Albin, author of research published in the Journal of Biological Chemistry, the VIF protein also interacts with an antiviral protein, namely APOBEC3F. They also found that these interactions might be disturbed by small changes in surface chemistry APOBEC3F.
"This shows the interaction between the VIF and antiviral APOBEC proteins can be blocked with a drug that will fortify VIF interaction region. Such interventions have the potential to make as many as seven developing natural antiviral drugs and to prevent HIV spread," said Albin.
Further study is needed to involve more detailed mapping of physical interactions between VIF and APOBEC3 proteins, investigation of potential HIV reject changes that stabilize the APOBEC3 proteins, and components such as drugs that can help destroy APOBEC HIV.
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